This can lead to the formation of transition or transversion mutations.Ī transition mutation is a point mutation that changes a purine nucleotide to another purine (A ↔ G) or a pyrimidine nucleotide to another pyrimidine (C ↔ T). For example, an adenine-containing nucleotide will often be added across a lesion, regardless of what the correct match should be.
If a DNA polymerase encounters a damaged DNA base in the template DNA during replication it may place a random nucleotide base across from the lesion. The next section will highlight common types of DNA damage and their effects.
DNA mutations can also result through the replication of DNA that has been damaged by endogenous or exogenous agents. Even with such high fidelity, this error rate will lead to between 3 and 3,000 errors within the human genome for each cell undergoing DNA replication. With these safeguards, their error rates are typically very low and range from one in a million bases to one in a billion bases. As noted in chapter 9, DNA polymerases are highly processive enzymes that contain proofreading and editing functions. For example, DNA mutations can be caused by mistakes made by the DNA polymerase during replication.
They can be large scale, altering the structure of the chromosomes, or small scale where they only alter a few or even a single base or nucleotide. Mutations are random changes that occur within the sequence of bases in DNA.
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